| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM50313480 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_617379 (CHEMBL1101890) |
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| IC50 | 1711±n/a nM |
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| Citation |  Rankovic, Z; Cai, J; Kerr, J; Fradera, X; Robinson, J; Mistry, A; Hamilton, E; McGarry, G; Andrews, F; Caulfield, W; Cumming, I; Dempster, M; Waller, J; Scullion, P; Martin, I; Mitchell, A; Long, C; Baugh, M; Westwood, P; Kinghorn, E; Bruin, J; Hamilton, W; Uitdehaag, J; van Zeeland, M; Potin, D; Saniere, L; Fouquet, A; Chevallier, F; Deronzier, H; Dorleans, C; Nicolai, E Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg Med Chem Lett20:1524-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM50313480 |
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| n/a |
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| Name | BDBM50313480 |
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| Synonyms: | 4-(cyclohexylamino)-6-(piperazin-1-yl)-1,3,5-triazine-2-carbonitrile | 4-(cyclohexylamino)-6-piperazin-1-yl-1,3,5-triazine-2-carbonitrile | CHEMBL1084679 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H21N7 |
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| Mol. Mass. | 287.3634 |
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| SMILES | N#Cc1nc(NC2CCCCC2)nc(n1)N1CCNCC1 |
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| Structure | 
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