Reaction Details |
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Target | Mannose-6-phosphate isomerase |
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Ligand | BDBM44439 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747525 (CHEMBL1777059) |
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IC50 | 6400±n/a nM |
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Citation | Dahl, R; Bravo, Y; Sharma, V; Ichikawa, M; Dhanya, RP; Hedrick, M; Brown, B; Rascon, J; Vicchiarelli, M; Mangravita-Novo, A; Yang, L; Stonich, D; Su, Y; Smith, LH; Sergienko, E; Freeze, HH; Cosford, ND Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem54:3661-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mannose-6-phosphate isomerase |
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Name: | Mannose-6-phosphate isomerase |
Synonyms: | MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1 |
Type: | PROTEIN |
Mol. Mass.: | 46651.35 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448919 |
Residue: | 423 |
Sequence: | MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
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BDBM44439 |
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n/a |
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Name | BDBM44439 |
Synonyms: | 2-(3-pyrrolidin-1-ylquinoxalin-2-yl)-2-thiophen-2-ylsulfonyl-ethanenitrile | 2-(3-pyrrolidin-1-ylquinoxalin-2-yl)-2-thiophen-2-ylsulfonylacetonitrile | 2-(3-pyrrolidinoquinoxalin-2-yl)-2-(2-thienylsulfonyl)acetonitrile | 2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]-2-thiophen-2-ylsulfonylacetonitrile | MLS000042133 | SMR000048426 | cid_667182 |
Type | Small organic molecule |
Emp. Form. | C18H16N4O2S2 |
Mol. Mass. | 384.475 |
SMILES | O=S(=O)(C(C#N)c1nc2ccccc2nc1N1CCCC1)c1cccs1 |
Structure |
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