| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 2 |
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| Ligand | BDBM42539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_766671 (CHEMBL1827365) |
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| IC50 | 200±n/a nM |
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| Citation |  Swanson, DM; Wong, VD; Jablonowski, JA; Shah, C; Rudolph, DA; Dvorak, CA; Seierstad, M; Dvorak, LK; Morton, K; Nepomuceno, D; Atack, JR; Bonaventure, P; Lovenberg, TW; Carruthers, NI The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor. Bioorg Med Chem Lett21:5552-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 2 |
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| Name: | Neuropeptide Y receptor type 2 |
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| Synonyms: | NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42734.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NPY-Y2 NPY2R HUMAN::P49146 |
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| Residue: | 381 |
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| Sequence: | MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV
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| BDBM42539 |
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| n/a |
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| Name | BDBM42539 |
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| Synonyms: | 4-(Hydroxy-diphenyl-methyl)-piperidine-1-carbothioic acid (4-ethoxy-phenyl)-amide | 4-[hydroxy(diphenyl)methyl]-N-p-phenetyl-piperidine-1-carbothioamide | MLS000569101 | N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide | N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide | N-(4-ethoxyphenyl)-4-[oxidanyl(diphenyl)methyl]piperidine-1-carbothioamide | SMR000177227 | cid_2936384 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N2O2S |
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| Mol. Mass. | 446.604 |
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| SMILES | CCOc1ccc(NC(=S)N2CCC(CC2)C(O)(c2ccccc2)c2ccccc2)cc1 |
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| Structure | 
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