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TargetGastrin/cholecystokinin type B receptor
LigandBDBM50044040
Substrate/Competitorn/a
Meas. Tech.ChEMBL_47833 (CHEMBL662575)
IC50 4800±n/a nM
Citation Elliott, RL; Kopecka, H; Bennett, MJ; Shue, YK; Craig, R; Lin, CW; Bianchi, BR; Miller, TR; Witte, DG; Stashko, MA Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus. J Med Chem37:309-13 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gastrin/cholecystokinin type B receptor
Name:Gastrin/cholecystokinin type B receptor
Synonyms:CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48445.79
Organism:Homo sapiens (Human)
Description:Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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  Blast E-value cutoff:
BDBM50044040
n/a
NameBDBM50044040
Synonyms:(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-[(S)-3-1H-indol-3-yl-2-(3-methyl-ureido)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | CHEMBL319439
TypeSmall organic molecule
Emp. Form.C41H51N9O8
Mol. Mass.797.8991
SMILESCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(O)=O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O
Structure
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