| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50065511 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_64042 (CHEMBL873580) |
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| IC50 | 10000±n/a nM |
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| Citation |  Astles, PC; Brealey, C; Brown, TJ; Facchini, V; Handscombe, C; Harris, NV; McCarthy, C; McLay, IM; Porter, B; Roach, AG; Sargent, C; Smith, C; Walsh, RJ Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives. J Med Chem41:2732-44 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49483.43 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN B EDNRB RAT::P21451 |
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| Residue: | 442 |
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| Sequence: | MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSN
SSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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| BDBM50065511 |
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| n/a |
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| Name | BDBM50065511 |
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| Synonyms: | (S)-4-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-4-o-tolyl-butyric acid | CHEMBL94141 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21NO4S |
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| Mol. Mass. | 407.482 |
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| SMILES | Cc1ccccc1[C@H](CCC(O)=O)Oc1cc(OCc2ccsc2)ccc1C#N |
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| Structure | 
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