| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor |
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| Ligand | BDBM50116620 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_146890 (CHEMBL751665) |
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| Ki | 1744±n/a nM |
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| Citation |  Thomas, JB; Atkinson, RN; Namdev, N; Rothman, RB; Gigstad, KM; Fix, SE; Mascarella, SW; Burgess, JP; Vinson, NA; Xu, H; Dersch, CM; Cantrell, BE; Zimmerman, DM; Carroll, FI Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans. J Med Chem45:3524-30 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Delta-type opioid receptor |
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| Name: | Delta-type opioid receptor |
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| Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40465.04 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. |
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| Residue: | 372 |
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| Sequence: | MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA
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|
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| BDBM50116620 |
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| n/a |
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| Name | BDBM50116620 |
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| Synonyms: | 4-Guanidino-N-[5-(3-hydroxy-phenyl)-4-methyl-2-phenethyl-2-aza-bicyclo[3.3.1]non-7-yl]-butyramide | CHEMBL118282 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H39N5O2 |
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| Mol. Mass. | 477.6416 |
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| SMILES | CC1CN(CCc2ccccc2)C2C[C@@H](CC1(C2)c1cccc(O)c1)NC(=O)CCCNC(N)=N |THB:0:1:17:13.14.15,4:3:17:13.14.15| |
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| Structure | 
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