| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 1A2 |
|---|
| Ligand | BDBM50218116 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_444857 (CHEMBL895108) |
|---|
| IC50 | >200000±n/a nM |
|---|
| Citation |  Dziadulewicz, EK; Bevan, SJ; Brain, CT; Coote, PR; Culshaw, AJ; Davis, AJ; Edwards, LJ; Fisher, AJ; Fox, AJ; Gentry, C; Groarke, A; Hart, TW; Huber, W; James, IF; Kesingland, A; La Vecchia, L; Loong, Y; Lyothier, I; McNair, K; O'Farrell, C; Peacock, M; Portmann, R; Schopfer, U; Yaqoob, M; Zadrobilek, J Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J Med Chem50:3851-6 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 1A2 |
|---|
| Name: | Cytochrome P450 1A2 |
|---|
| Synonyms: | CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 58423.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05177 |
|---|
| Residue: | 516 |
|---|
| Sequence: | MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
|
|
|
|---|
| BDBM50218116 |
|---|
| n/a |
|---|
| Name | BDBM50218116 |
|---|
| Synonyms: | CHEMBL244403 | naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H24O2 |
|---|
| Mol. Mass. | 368.4676 |
|---|
| SMILES | CCCCCOc1ccc(C(=O)c2cccc3ccccc23)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
