| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
|---|
| Ligand | BDBM50378592 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_605690 (CHEMBL1071220) |
|---|
| IC50 | >1000±n/a nM |
|---|
| Citation |  Singhaus, RR; Bernotas, RC; Steffan, R; Matelan, E; Quinet, E; Nambi, P; Feingold, I; Huselton, C; Wilhelmsson, A; Goos-Nilsson, A; Wrobel, J 3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists. Bioorg Med Chem Lett20:521-5 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Oxysterols receptor LXR-beta |
|---|
| Name: | Oxysterols receptor LXR-beta |
|---|
| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 50978.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P55055 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
|
|
|
|---|
| BDBM50378592 |
|---|
| n/a |
|---|
| Name | BDBM50378592 |
|---|
| Synonyms: | CHEMBL612006 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H26F3N3O3S |
|---|
| Mol. Mass. | 529.574 |
|---|
| SMILES | CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(CN3CCCCC3)nc3c(cccn23)C(F)(F)F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
