| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 2 |
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| Ligand | BDBM50336808 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_718679 (CHEMBL1680830) |
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| IC50 | 50000±n/a nM |
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| Citation |  Miyamoto, Y; Banno, Y; Yamashita, T; Fujimoto, T; Oi, S; Moritoh, Y; Asakawa, T; Kataoka, O; Yashiro, H; Takeuchi, K; Suzuki, N; Ikedo, K; Kosaka, T; Tsubotani, S; Tani, A; Sasaki, M; Funami, M; Amano, M; Yamamoto, Y; Aertgeerts, K; Yano, J; Maezaki, H Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor. J Med Chem54:831-50 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 2 |
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| Name: | Dipeptidyl peptidase 2 |
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| Synonyms: | DPP2_RAT | Dipeptidyl peptidase II | Dpp2 | Dpp7 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55100.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_718679 |
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| Residue: | 500 |
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| Sequence: | MGLHPCSPVDHGVPSWVLVLLLTLGLCSLQATADSVLDPDFRENYFEQYMDHFNFESFSN
KTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSLANNSGFIVELAAQQEALLVFAEHRYY
GKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRHNLGVQDAPTIAFGGSYGGMLSAY
MRMKYPHLVAGALAASAPVIAVAGLGNPDQFFRDVTADFYGQSPKCAQAVRDAFQQIKDL
FLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMMDYPYPTNFLGPLPANPVK
VGCERLLSEGQRIMGLRALAGLVYNSSGMEPCFDIYQMYQSCADPTGCGTGSNARAWDYQ
ACTEINLTFDSNNVTDMFPEIPFSDELRQQYCLDTWGVWPRPDWLQTSFWGGDLKAASNI
IFSNGDLDPWAGGGIQRNLSTSIIAVTIQGGAHHLDLRASNSEDPPSVVEVRKLEATLIR
EWVAAARLKQPAEAQWPGPK
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| BDBM50336808 |
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| n/a |
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| Name | BDBM50336808 |
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| Synonyms: | CHEMBL1672115 | [5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]acetic Acid Dihydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N2O2 |
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| Mol. Mass. | 326.4326 |
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| SMILES | CC(C)Cc1nc(C)c(CC(O)=O)c(-c2ccc(C)cc2)c1CN |
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| Structure | 
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