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TargetRenin
LigandBDBM50382336
Substrate/Competitorn/a
Meas. Tech.ChEMBL_817423 (CHEMBL2027646)
IC50 4.5±n/a nM
Citation Jia, LSimpson, RDYuan, JXu, ZZhao, WCacatian, STice, CMGuo, JIshchenko, ASingh, SBWu, ZMcKeever, BMBukhtiyarov, YJohnson, JADoe, CPHarrison, RKMcGeehan, GMDillard, LWBaldwin, JJClaremon, DA Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. ACS Med Chem Lett2:747-751 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50382336
n/a
NameBDBM50382336
Synonyms:CHEMBL2023122
TypeSmall organic molecule
Emp. Form.C26H41ClN4O5
Mol. Mass.525.081
SMILESCNC[C@H](C[C@@H]1CCCOC1)NC(=O)N1CCC[C@H](C1)[C@@H](OCCNC(=O)OC)c1cccc(Cl)c1 |r|
Structure
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