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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bcl-2-like protein 1 | ||
| Ligand | BDBM50384318 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_818166 (CHEMBL2033943) | ||
| IC50 | 18±n/a nM | ||
| Citation |  Schroeder, GM; Wei, D; Banfi, P; Cai, ZW; Lippy, J; Menichincheri, M; Modugno, M; Naglich, J; Penhallow, B; Perez, HL; Sack, J; Schmidt, RJ; Tebben, A; Yan, C; Zhang, L; Galvani, A; Lombardo, LJ; Borzilleri, RM Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorg Med Chem Lett22:3951-6 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bcl-2-like protein 1 | |||
| Name: | Bcl-2-like protein 1 | ||
| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) | ||
| Type: | Mitochondrion membrane; Single-pass membrane protein | ||
| Mol. Mass.: | 26039.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 233 | ||
| Sequence: |
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| BDBM50384318 | |||
| n/a | |||
| Name | BDBM50384318 | ||
| Synonyms: | CHEMBL2030853 | US9346795, 243 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C47H41ClN4O6S | ||
| Mol. Mass. | 825.37 | ||
| SMILES | CCCCc1c(c(CO)nn1-c1ccc(Oc2cccc(Cl)c2)cc1)-c1ccc(cc1C(=O)N1CCc2ccccc2C1)C(=O)NS(=O)(=O)c1ccc2ccccc2c1 |(-1.41,-6.84,;-2.72,-6.03,;-2.67,-4.49,;-3.99,-3.68,;-3.94,-2.14,;-3.78,-.6,;-5.18,.02,;-5.5,1.53,;-6.97,2,;-6.22,-1.12,;-5.45,-2.46,;-6.17,-3.81,;-7.71,-3.86,;-8.44,-5.21,;-7.63,-6.52,;-8.35,-7.88,;-7.53,-9.19,;-8.27,-10.54,;-7.45,-11.85,;-5.91,-11.8,;-5.19,-10.43,;-3.65,-10.37,;-6,-9.13,;-6.08,-6.47,;-5.36,-5.11,;-2.44,.16,;-2.44,1.7,;-1.1,2.48,;.23,1.7,;.23,.16,;-1.11,-.61,;-1.12,-2.15,;-2.46,-2.91,;.21,-2.92,;.21,-4.46,;1.53,-5.23,;2.86,-4.47,;4.18,-5.25,;5.53,-4.5,;5.54,-2.96,;4.21,-2.17,;2.88,-2.93,;1.55,-2.15,;1.57,2.46,;1.58,4,;2.9,1.69,;4.23,2.45,;3.45,3.78,;4.99,3.79,;5.57,1.67,;5.56,.13,;6.89,-.65,;8.24,.13,;9.58,-.63,;10.92,.15,;10.9,1.71,;9.55,2.46,;8.23,1.68,;6.9,2.45,)| | ||
| Structure | 
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