Reaction Details |
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Target | Sodium/glucose cotransporter 2 |
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Ligand | BDBM20875 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_856137 (CHEMBL2162525) |
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IC50 | 96±n/a nM |
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Citation | Fushimi, N; Fujikura, H; Shiohara, H; Teranishi, H; Shimizu, K; Yonekubo, S; Ohno, K; Miyagi, T; Itoh, F; Shibazaki, T; Tomae, M; Ishikawa-Takemura, Y; Nakabayashi, T; Kamada, N; Ozawa, T; Kobayashi, S; Isaji, M Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-ylß-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia. Bioorg Med Chem20:6598-612 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 2 |
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Name: | Sodium/glucose cotransporter 2 |
Synonyms: | SC5A2_RAT | Sglt2 | Slc5a2 |
Type: | PROTEIN |
Mol. Mass.: | 72969.23 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_938467 |
Residue: | 670 |
Sequence: | MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTV
SKDPAVGNISSTCYQPRPDSYHLLRDPVTGGLPWPALLLGLTIVSGWHWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDREL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTL
AISRCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQS
PAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMT
VAVFLWGFYA
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BDBM20875 |
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n/a |
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Name | BDBM20875 |
Synonyms: | 1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one | CHEMBL241384 | CHEMBL245067 | JMC511145 Compound 1 | O-glucoside, 1 | Phlorizin |
Type | Natural product |
Emp. Form. | C21H24O10 |
Mol. Mass. | 436.4093 |
SMILES | OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O |
Structure |
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