Reaction Details |
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Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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Ligand | BDBM50395692 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_860056 (CHEMBL2167992) |
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IC50 | 230±n/a nM |
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Citation | Deng, H; O'Keefe, H; Davie, CP; Lind, KE; Acharya, RA; Franklin, GJ; Larkin, J; Matico, R; Neeb, M; Thompson, MM; Lohr, T; Gross, JW; Centrella, PA; O'Donovan, GK; Bedard, KL; van Vloten, K; Mataruse, S; Skinner, SR; Belyanskaya, SL; Carpenter, TY; Shearer, TW; Clark, MA; Cuozzo, JW; Arico-Muendel, CC; Morgan, BA Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT). J Med Chem55:7061-79 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) | ADAMTS11 | ADAMTS5 | ADMP2 | ATS5_HUMAN | Aggrecanase-2 | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
Type: | Enzyme |
Mol. Mass.: | 101769.09 |
Organism: | Homo sapiens (Human) |
Description: | Q9UNA0 |
Residue: | 930 |
Sequence: | MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
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BDBM50395692 |
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n/a |
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Name | BDBM50395692 |
Synonyms: | CHEMBL2163736 |
Type | Small organic molecule |
Emp. Form. | C28H32N8O2S2 |
Mol. Mass. | 576.736 |
SMILES | C=CCCNc1nc(NCc2csc(n2)-c2ccccc2)nc(n1)N1CCC[C@@H]1CNS(=O)(=O)c1ccccc1 |r| |
Structure |
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