Reaction Details |
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Target | Cytochrome P450 3A4 |
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Ligand | BDBM50418123 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_741384 (CHEMBL1764910) |
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IC50 | <3162±n/a nM |
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Citation | Evans, KA; Shearer, BG; Wisnoski, DD; Shi, D; Sparks, SM; Sternbach, DD; Winegar, DA; Billin, AN; Britt, C; Way, JM; Epperly, AH; Leesnitzer, LM; Merrihew, RV; Xu, RX; Lambert, MH; Jin, J Phenoxyacetic acids as PPARd partial agonists: synthesis, optimization, and in vivo efficacy. Bioorg Med Chem Lett21:2345-50 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 3A4 |
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Name: | Cytochrome P450 3A4 |
Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 57349.57 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 503 |
Sequence: | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
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BDBM50418123 |
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n/a |
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Name | BDBM50418123 |
Synonyms: | CHEMBL1760005 |
Type | Small organic molecule |
Emp. Form. | C28H29ClF3NO6S |
Mol. Mass. | 600.046 |
SMILES | CCCCN(c1cccc(-c2ccc(OC(F)(F)F)cc2)c1Cl)S(=O)(=O)c1ccc(OC(C)C(O)=O)c(C)c1C |
Structure |
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