Reaction Details |
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Target | Arginase-2, mitochondrial |
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Ligand | BDBM50439238 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_978892 (CHEMBL2423683) |
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IC50 | 240±n/a nM |
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Citation | Golebiowski, A; Whitehouse, D; Beckett, RP; Van Zandt, M; Ji, MK; Ryder, TR; Jagdmann, E; Andreoli, M; Lee, Y; Sheeler, R; Conway, B; Olczak, J; Mazur, M; Czestkowski, W; Piotrowska, W; Cousido-Siah, A; Ruiz, FX; Mitschler, A; Podjarny, A; Schroeter, H Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg Med Chem Lett23:4837-41 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Arginase-2, mitochondrial |
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Name: | Arginase-2, mitochondrial |
Synonyms: | ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase |
Type: | PROTEIN |
Mol. Mass.: | 38576.93 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_978892 |
Residue: | 354 |
Sequence: | MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS
LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH
SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ
LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
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BDBM50439238 |
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n/a |
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Name | BDBM50439238 |
Synonyms: | CHEMBL2418995 |
Type | Small organic molecule |
Emp. Form. | C18H28BClN2O4 |
Mol. Mass. | 382.69 |
SMILES | NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)cc2)CC1)C(O)=O |
Structure |
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