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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Oxysterols receptor LXR-alpha | ||
| Ligand | BDBM50034778 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1441018 (CHEMBL3377014) | ||
| EC50 | >10000±n/a nM | ||
| Citation |  Kick, E; Martin, R; Xie, Y; Flatt, B; Schweiger, E; Wang, TL; Busch, B; Nyman, M; Gu, XH; Yan, G; Wagner, B; Nanao, M; Nguyen, L; Stout, T; Plonowski, A; Schulman, I; Ostrowski, J; Kirchgessner, T; Wexler, R; Mohan, R Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRß. Bioorg Med Chem Lett25:372-7 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Oxysterols receptor LXR-alpha | |||
| Name: | Oxysterols receptor LXR-alpha | ||
| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 50403.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13133 | ||
| Residue: | 447 | ||
| Sequence: |
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| BDBM50034778 | |||
| n/a | |||
| Name | BDBM50034778 | ||
| Synonyms: | CHEMBL3360972 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H22Cl2N2O3S | ||
| Mol. Mass. | 501.425 | ||
| SMILES | CC(C)(O)c1cn(c(n1)-c1c(Cl)cccc1Cl)-c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O |(.07,-55.05,;1.6,-55.21,;2.22,-56.62,;.5,-56.3,;2.5,-53.97,;4.04,-53.97,;4.53,-52.5,;3.27,-51.6,;2.03,-52.51,;3.27,-50.06,;1.94,-49.3,;.61,-50.08,;1.93,-47.77,;3.27,-46.98,;4.61,-47.75,;4.61,-49.29,;6.09,-48.88,;5.84,-51.71,;7.18,-52.45,;8.5,-51.66,;8.47,-50.12,;7.12,-49.38,;5.8,-50.17,;9.79,-49.32,;11.14,-50.07,;12.45,-49.27,;12.42,-47.73,;11.06,-46.99,;9.75,-47.79,;11.02,-45.45,;12.34,-44.64,;9.53,-45.04,;10.62,-43.95,)| | ||
| Structure | 
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