Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 4 |
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Ligand | BDBM50095463 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1504266 (CHEMBL3592269) |
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IC50 | 150±n/a nM |
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Citation | Lim, J; Altman, MD; Baker, J; Brubaker, JD; Chen, H; Chen, Y; Fischmann, T; Gibeau, C; Kleinschek, MA; Leccese, E; Lesburg, C; Maclean, JK; Moy, LY; Mulrooney, EF; Presland, J; Rakhilina, L; Smith, GF; Steinhuebel, D; Yang, R Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS Med Chem Lett6:683-8 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 4 |
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Name: | Interleukin-1 receptor-associated kinase 4 |
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
Type: | Protein |
Mol. Mass.: | 51519.08 |
Organism: | Homo sapiens (Human) |
Description: | Q9NWZ3 |
Residue: | 460 |
Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM50095463 |
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n/a |
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Name | BDBM50095463 |
Synonyms: | CHEMBL3590436 | US9649308, Example 40 |
Type | Small organic molecule |
Emp. Form. | C15H18N8O2 |
Mol. Mass. | 342.3558 |
SMILES | Cn1cc(NC(=O)c2cnn3ccc(CCCN)nc23)c(n1)C(N)=O |
Structure |
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