Reaction Details |
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Target | Motilin receptor |
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Ligand | BDBM9488 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1574692 (CHEMBL3801559) |
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Ki | 19000±n/a nM |
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Citation | Mandal, M; Wu, Y; Misiaszek, J; Li, G; Buevich, A; Caldwell, JP; Liu, X; Mazzola, RD; Orth, P; Strickland, C; Voigt, J; Wang, H; Zhu, Z; Chen, X; Grzelak, M; Hyde, LA; Kuvelkar, R; Leach, PT; Terracina, G; Zhang, L; Zhang, Q; Michener, MS; Smith, B; Cox, K; Grotz, D; Favreau, L; Mitra, K; Kazakevich, I; McKittrick, BA; Greenlee, W; Kennedy, ME; Parker, EM; Cumming, JN; Stamford, AW Structure-Based Design of an Iminoheterocyclicß-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aß in Nonhuman Primates. J Med Chem59:3231-48 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Motilin receptor |
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Name: | Motilin receptor |
Synonyms: | G-protein coupled receptor 38 | GPR38 | MLNR | MTLR | MTLR1 | MTLR_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 45365.95 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_122664 |
Residue: | 412 |
Sequence: | MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
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BDBM9488 |
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n/a |
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Name | BDBM9488 |
Synonyms: | US8541427, 1 |
Type | n/a |
Emp. Form. | C19H19F3N6O2 |
Mol. Mass. | 420.3884 |
SMILES | COc1nc(nc(C)c1F)N1C[C@H]2C(=O)N(C)C(=N)N[C@]2(C1)c1ccc(F)cc1F |r| |
Structure |
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