Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50206392 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1628980 (CHEMBL3871606) |
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IC50 | 64±n/a nM |
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Citation | Chang, CF; Lin, WH; Ke, YY; Lin, YS; Wang, WC; Chen, CH; Kuo, PC; Hsu, JTA; Uang, BJ; Hsieh, HP Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design. Eur J Med Chem124:186-199 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50206392 |
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n/a |
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Name | BDBM50206392 |
Synonyms: | CHEMBL3922175 |
Type | Small organic molecule |
Emp. Form. | C25H24N4O5S |
Mol. Mass. | 492.547 |
SMILES | CCOC(=O)CCC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 |
Structure |
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