Compile Data Set for Download or QSAR

Found 105 hits with Last Name = 'chang' and Initial = 'cf'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50004205 (MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged Aurora A (1 to 403 residues) (unknown origin) expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase C (Homo sapiens (Human))	BDBM50004205 (MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged Aurora C (1 to 309 residues) (unknown origin) expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50004205 (MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged Aurora B (62 to 344 residues) (unknown origin) expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50175305 (CHEMBL3600873) Show SMILES OC(=O)[C@@]1(Cc2cccc(Nc3nccs3)n2)CC[C@@H](CC1)Oc1cccc(Cl)c1F |r,wU:3.2,wD:19.24,(2.4,1.65,;1.33,2.27,;1.34,3.5,;,1.54,;-1.33,2.27,;-2.67,1.5,;-2.64,-.04,;-3.96,-.84,;-5.31,-.09,;-5.34,1.45,;-6.69,2.19,;-8,1.39,;-8.11,-.13,;-9.61,-.48,;-10.41,.83,;-9.4,2,;-4.02,2.24,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;0,-3.08,;1.34,-3.85,;2.67,-3.07,;4.01,-3.84,;4.01,-5.38,;2.68,-6.15,;2.68,-7.39,;1.34,-5.39,;.28,-6.01,)| Show InChI InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.0460	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged Aurora A expressed in Escherichia coli using RRR(GLRRASLG)4R-NH2 as substrate after 40 mins in presence of...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50206389 (CHEMBL3939307) Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H20N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-8,10-11,13-14H,9,12H2,1H3,(H,23,27)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of VEGFR1 (unknown origin)				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50206389 (CHEMBL3939307) Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H20N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-8,10-11,13-14H,9,12H2,1H3,(H,23,27)(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of VEGFR3 (unknown origin)				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50206389 (CHEMBL3939307) Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H20N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-8,10-11,13-14H,9,12H2,1H3,(H,23,27)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin)				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370502 (CHEMBL4161600) Show SMILES CCN(C)Cc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C31H31ClN6O2/c1-3-38(2)19-22-8-7-11-25(18-22)37-31(39)36-24-14-12-21(13-15-24)16-17-33-29-26-27(32)28(23-9-5-4-6-10-23)40-30(26)35-20-34-29/h4-15,18,20H,3,16-17,19H2,1-2H3,(H,33,34,35)(H2,36,37,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase C (Homo sapiens (Human))	BDBM50175305 (CHEMBL3600873) Show SMILES OC(=O)[C@@]1(Cc2cccc(Nc3nccs3)n2)CC[C@@H](CC1)Oc1cccc(Cl)c1F |r,wU:3.2,wD:19.24,(2.4,1.65,;1.33,2.27,;1.34,3.5,;,1.54,;-1.33,2.27,;-2.67,1.5,;-2.64,-.04,;-3.96,-.84,;-5.31,-.09,;-5.34,1.45,;-6.69,2.19,;-8,1.39,;-8.11,-.13,;-9.61,-.48,;-10.41,.83,;-9.4,2,;-4.02,2.24,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;0,-3.08,;1.34,-3.85,;2.67,-3.07,;4.01,-3.84,;4.01,-5.38,;2.68,-6.15,;2.68,-7.39,;1.34,-5.39,;.28,-6.01,)| Show InChI InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length N-terminal GST-tagged Aurora C (1 to 275 end residues) expressed in baculovirus expression system using G...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50175305 (CHEMBL3600873) Show SMILES OC(=O)[C@@]1(Cc2cccc(Nc3nccs3)n2)CC[C@@H](CC1)Oc1cccc(Cl)c1F |r,wU:3.2,wD:19.24,(2.4,1.65,;1.33,2.27,;1.34,3.5,;,1.54,;-1.33,2.27,;-2.67,1.5,;-2.64,-.04,;-3.96,-.84,;-5.31,-.09,;-5.34,1.45,;-6.69,2.19,;-8,1.39,;-8.11,-.13,;-9.61,-.48,;-10.41,.83,;-9.4,2,;-4.02,2.24,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;0,-3.08,;1.34,-3.85,;2.67,-3.07,;4.01,-3.84,;4.01,-5.38,;2.68,-6.15,;2.68,-7.39,;1.34,-5.39,;.28,-6.01,)| Show InChI InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length N-terminal GST-tagged Aurora B (1 to 344 end residues) expressed in baculovirus expression system coexpre...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206412 (CHEMBL3986609) Show SMILES OC(=O)\C=C/C(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C23H18N4O5S/c28-21(11-12-22(29)30)24-16-6-4-5-15(13-16)23-19-14-17(9-10-20(19)25-26-23)27-33(31,32)18-7-2-1-3-8-18/h1-14,27H,(H,24,28)(H,25,26)(H,29,30)/b12-11-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370442 (CHEMBL4175638) Show SMILES CN(C)Cc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C30H29ClN6O2/c1-37(2)18-21-7-6-10-24(17-21)36-30(38)35-23-13-11-20(12-14-23)15-16-32-28-25-26(31)27(22-8-4-3-5-9-22)39-29(25)34-19-33-28/h3-14,17,19H,15-16,18H2,1-2H3,(H,32,33,34)(H2,35,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370444 (CHEMBL4172214) Show SMILES CCN(CC)Cc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C32H33ClN6O2/c1-3-39(4-2)20-23-9-8-12-26(19-23)38-32(40)37-25-15-13-22(14-16-25)17-18-34-30-27-28(33)29(24-10-6-5-7-11-24)41-31(27)36-21-35-30/h5-16,19,21H,3-4,17-18,20H2,1-2H3,(H,34,35,36)(H2,37,38,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370445 (CHEMBL4162506) Show SMILES CN(C)Cc1ccccc1NC(=O)Nc1ccc(CCNc2ncnc3oc(c(Cl)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C30H29ClN6O2/c1-37(2)18-22-10-6-7-11-24(22)36-30(38)35-23-14-12-20(13-15-23)16-17-32-28-25-26(31)27(21-8-4-3-5-9-21)39-29(25)34-19-33-28/h3-15,19H,16-18H2,1-2H3,(H,32,33,34)(H2,35,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of Aurora-B autophosphorylation at Thr232 in human HCT116 cells after 1 hr by Western blot analysis				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50206412 (CHEMBL3986609) Show SMILES OC(=O)\C=C/C(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C23H18N4O5S/c28-21(11-12-22(29)30)24-16-6-4-5-15(13-16)23-19-14-17(9-10-20(19)25-26-23)27-33(31,32)18-7-2-1-3-8-18/h1-14,27H,(H,24,28)(H,25,26)(H,29,30)/b12-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged Aurora A (123 to 401 residues) (unknown origin) preincubated for 15 mins followed by tetra(LRRWSLG) substrate addition measu...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206393 (CHEMBL3954695) Show SMILES OC(=O)\C=C/C(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccc(cc3)[N+]([O-])=O)cc12 Show InChI InChI=1S/C23H17N5O7S/c29-21(10-11-22(30)31)24-15-3-1-2-14(12-15)23-19-13-16(4-9-20(19)25-26-23)27-36(34,35)18-7-5-17(6-8-18)28(32)33/h1-13,27H,(H,24,29)(H,25,26)(H,30,31)/b11-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206406 (CHEMBL3975342) Show SMILES OC(=O)CCC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C23H20N4O5S/c28-21(11-12-22(29)30)24-16-6-4-5-15(13-16)23-19-14-17(9-10-20(19)25-26-23)27-33(31,32)18-7-2-1-3-8-18/h1-10,13-14,27H,11-12H2,(H,24,28)(H,25,26)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206409 (CHEMBL3983327) Show SMILES OC(=O)\C=C/C(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccc(F)cc3)cc12 Show InChI InChI=1S/C23H17FN4O5S/c24-15-4-7-18(8-5-15)34(32,33)28-17-6-9-20-19(13-17)23(27-26-20)14-2-1-3-16(12-14)25-21(29)10-11-22(30)31/h1-13,28H,(H,25,29)(H,26,27)(H,30,31)/b11-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206391 (CHEMBL3894492) Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc2[nH]nc(-c3cccc(NC(=O)\C=C/C(O)=O)c3)c2c1 Show InChI InChI=1S/C24H20N4O6S/c1-34-18-6-8-19(9-7-18)35(32,33)28-17-5-10-21-20(14-17)24(27-26-21)15-3-2-4-16(13-15)25-22(29)11-12-23(30)31/h2-14,28H,1H3,(H,25,29)(H,26,27)(H,30,31)/b12-11-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206413 (CHEMBL3974375) Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2[nH]nc(-c3cccc(NC(=O)\C=C/C(O)=O)c3)c2c1 Show InChI InChI=1S/C24H20N4O5S/c1-15-5-8-19(9-6-15)34(32,33)28-18-7-10-21-20(14-18)24(27-26-21)16-3-2-4-17(13-16)25-22(29)11-12-23(30)31/h2-14,28H,1H3,(H,25,29)(H,26,27)(H,30,31)/b12-11-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370445 (CHEMBL4162506) Show SMILES CN(C)Cc1ccccc1NC(=O)Nc1ccc(CCNc2ncnc3oc(c(Cl)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C30H29ClN6O2/c1-37(2)18-22-10-6-7-11-24(22)36-30(38)35-23-14-12-20(13-15-23)16-17-32-28-25-26(31)27(21-8-4-3-5-9-21)39-29(25)34-19-33-28/h3-15,19H,16-18H2,1-2H3,(H,32,33,34)(H2,35,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206408 (CHEMBL3939365) Show SMILES COC(=O)CCC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C24H22N4O5S/c1-33-23(30)13-12-22(29)25-17-7-5-6-16(14-17)24-20-15-18(10-11-21(20)26-27-24)28-34(31,32)19-8-3-2-4-9-19/h2-11,14-15,28H,12-13H2,1H3,(H,25,29)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206415 (CHEMBL3923159) Show SMILES NC(=O)CCC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C23H21N5O4S/c24-21(29)11-12-22(30)25-16-6-4-5-15(13-16)23-19-14-17(9-10-20(19)26-27-23)28-33(31,32)18-7-2-1-3-8-18/h1-10,13-14,28H,11-12H2,(H2,24,29)(H,25,30)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50206407 (CHEMBL3946005) Show SMILES OC(=O)\C=C\C(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C23H18N4O5S/c28-21(11-12-22(29)30)24-16-6-4-5-15(13-16)23-19-14-17(9-10-20(19)25-26-23)27-33(31,32)18-7-2-1-3-8-18/h1-14,27H,(H,24,28)(H,25,26)(H,29,30)/b12-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged Aurora A (123 to 401 residues) (unknown origin) preincubated for 15 mins followed by tetra(LRRWSLG) substrate addition measu...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370514 (CHEMBL4171920) Show SMILES Clc1c(oc2ncnc(NCCc3ccc(NC(=O)Nc4ccccc4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C27H22ClN5O2/c28-23-22-25(30-17-31-26(22)35-24(23)19-7-3-1-4-8-19)29-16-15-18-11-13-21(14-12-18)33-27(34)32-20-9-5-2-6-10-20/h1-14,17H,15-16H2,(H,29,30,31)(H2,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370507 (CHEMBL4168861) Show SMILES Cc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C28H24ClN5O2/c1-18-6-5-9-22(16-18)34-28(35)33-21-12-10-19(11-13-21)14-15-30-26-23-24(29)25(20-7-3-2-4-8-20)36-27(23)32-17-31-26/h2-13,16-17H,14-15H2,1H3,(H,30,31,32)(H2,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370503 (CHEMBL4166291) Show SMILES Cc1ccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)cc1 Show InChI InChI=1S/C28H24ClN5O2/c1-18-7-11-21(12-8-18)33-28(35)34-22-13-9-19(10-14-22)15-16-30-26-23-24(29)25(20-5-3-2-4-6-20)36-27(23)32-17-31-26/h2-14,17H,15-16H2,1H3,(H,30,31,32)(H2,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370442 (CHEMBL4175638) Show SMILES CN(C)Cc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C30H29ClN6O2/c1-37(2)18-21-7-6-10-24(17-21)36-30(38)35-23-13-11-20(12-14-23)15-16-32-28-25-26(31)27(22-8-4-3-5-9-22)39-29(25)34-19-33-28/h3-14,17,19H,15-16,18H2,1-2H3,(H,32,33,34)(H2,35,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of Aurora-A autophosphorylation at Thr288 in human HCT116 cells after 1 hr by Western blot analysis				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50206409 (CHEMBL3983327) Show SMILES OC(=O)\C=C/C(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccc(F)cc3)cc12 Show InChI InChI=1S/C23H17FN4O5S/c24-15-4-7-18(8-5-15)34(32,33)28-17-6-9-20-19(13-17)23(27-26-20)14-2-1-3-16(12-14)25-21(29)10-11-22(30)31/h1-13,28H,(H,25,29)(H,26,27)(H,30,31)/b11-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged Aurora A (123 to 401 residues) (unknown origin) preincubated for 15 mins followed by tetra(LRRWSLG) substrate addition measu...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370495 (CHEMBL4159739) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(CCNc2ncnc3oc(c(Cl)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C28H24ClN5O2/c1-18-7-5-6-10-22(18)34-28(35)33-21-13-11-19(12-14-21)15-16-30-26-23-24(29)25(20-8-3-2-4-9-20)36-27(23)32-17-31-26/h2-14,17H,15-16H2,1H3,(H,30,31,32)(H2,33,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50206392 (CHEMBL3922175) Show SMILES CCOC(=O)CCC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C25H24N4O5S/c1-2-34-24(31)14-13-23(30)26-18-8-6-7-17(15-18)25-21-16-19(11-12-22(21)27-28-25)29-35(32,33)20-9-4-3-5-10-20/h3-12,15-16,29H,2,13-14H2,1H3,(H,26,30)(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50206415 (CHEMBL3923159) Show SMILES NC(=O)CCC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C23H21N5O4S/c24-21(29)11-12-22(30)25-16-6-4-5-15(13-16)23-19-14-17(9-10-20(19)26-27-23)28-33(31,32)18-7-2-1-3-8-18/h1-10,13-14,28H,11-12H2,(H2,24,29)(H,25,30)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged Aurora A (123 to 401 residues) (unknown origin) preincubated for 15 mins followed by tetra(LRRWSLG) substrate addition measu...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370514 (CHEMBL4171920) Show SMILES Clc1c(oc2ncnc(NCCc3ccc(NC(=O)Nc4ccccc4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C27H22ClN5O2/c28-23-22-25(30-17-31-26(22)35-24(23)19-7-3-1-4-8-19)29-16-15-18-11-13-21(14-12-18)33-27(34)32-20-9-5-2-6-10-20/h1-14,17H,15-16H2,(H,29,30,31)(H2,32,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370509 (CHEMBL4170043) Show SMILES CCc1ccccc1NC(=O)Nc1ccc(CCNc2ncnc3oc(c(Cl)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C29H26ClN5O2/c1-2-20-8-6-7-11-23(20)35-29(36)34-22-14-12-19(13-15-22)16-17-31-27-24-25(30)26(21-9-4-3-5-10-21)37-28(24)33-18-32-27/h3-15,18H,2,16-17H2,1H3,(H,31,32,33)(H2,34,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370446 (CHEMBL4173353) Show SMILES CCc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C23H30N6O3/c1-27-8-5-19(26-16-27)14-28-10-6-23(7-11-28,21(30)31)15-32-20-3-2-17-4-9-29(22(24)25)13-18(17)12-20/h2-3,5,8,12,16H,4,6-7,9-11,13-15H2,1H3,(H3-,24,25,30,31)/p+1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370499 (CHEMBL4163926) Show SMILES OC1CCN(Cc2cccc(NC(=O)Nc3ccc(CCNc4ncnc5oc(c(Cl)c45)-c4ccccc4)cc3)c2)CC1 Show InChI InChI=1S/C33H33ClN6O3/c34-29-28-31(36-21-37-32(28)43-30(29)24-6-2-1-3-7-24)35-16-13-22-9-11-25(12-10-22)38-33(42)39-26-8-4-5-23(19-26)20-40-17-14-27(41)15-18-40/h1-12,19,21,27,41H,13-18,20H2,(H,35,36,37)(H2,38,39,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370445 (CHEMBL4162506) Show SMILES CN(C)Cc1ccccc1NC(=O)Nc1ccc(CCNc2ncnc3oc(c(Cl)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C30H29ClN6O2/c1-37(2)18-22-10-6-7-11-24(22)36-30(38)35-23-14-12-20(13-15-23)16-17-32-28-25-26(31)27(21-8-4-3-5-9-21)39-29(25)34-19-33-28/h3-15,19H,16-18H2,1-2H3,(H,32,33,34)(H2,35,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of Aurora-A autophosphorylation at Thr288 in human HCT116 cells after 1 hr by Western blot analysis				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370503 (CHEMBL4166291) Show SMILES Cc1ccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)cc1 Show InChI InChI=1S/C28H24ClN5O2/c1-18-7-11-21(12-8-18)33-28(35)34-22-13-9-19(10-14-22)15-16-30-26-23-24(29)25(20-5-3-2-4-6-20)36-27(23)32-17-31-26/h2-14,17H,15-16H2,1H3,(H,30,31,32)(H2,33,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50206406 (CHEMBL3975342) Show SMILES OC(=O)CCC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C23H20N4O5S/c28-21(11-12-22(29)30)24-16-6-4-5-15(13-16)23-19-14-17(9-10-20(19)25-26-23)27-33(31,32)18-7-2-1-3-8-18/h1-10,13-14,27H,11-12H2,(H,24,28)(H,25,26)(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged Aurora A (123 to 401 residues) (unknown origin) preincubated for 15 mins followed by tetra(LRRWSLG) substrate addition measu...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370507 (CHEMBL4168861) Show SMILES Cc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C28H24ClN5O2/c1-18-6-5-9-22(16-18)34-28(35)33-21-12-10-19(11-13-21)14-15-30-26-23-24(29)25(20-7-3-2-4-8-20)36-27(23)32-17-31-26/h2-13,16-17H,14-15H2,1H3,(H,30,31,32)(H2,33,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370494 (CHEMBL4176720) Show SMILES OC1CCN(Cc2ccccc2NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)CC1 Show InChI InChI=1S/C33H33ClN6O3/c34-29-28-31(36-21-37-32(28)43-30(29)23-6-2-1-3-7-23)35-17-14-22-10-12-25(13-11-22)38-33(42)39-27-9-5-4-8-24(27)20-40-18-15-26(41)16-19-40/h1-13,21,26,41H,14-20H2,(H,35,36,37)(H2,38,39,42)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50206408 (CHEMBL3939365) Show SMILES COC(=O)CCC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C24H22N4O5S/c1-33-23(30)13-12-22(29)25-17-7-5-6-16(14-17)24-20-15-18(10-11-21(20)26-27-24)28-34(31,32)19-8-3-2-4-9-19/h2-11,14-15,28H,12-13H2,1H3,(H,25,29)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged Aurora A (123 to 401 residues) (unknown origin) preincubated for 15 mins followed by tetra(LRRWSLG) substrate addition measu...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370495 (CHEMBL4159739) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(CCNc2ncnc3oc(c(Cl)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C28H24ClN5O2/c1-18-7-5-6-10-22(18)34-28(35)33-21-13-11-19(12-14-21)15-16-30-26-23-24(29)25(20-8-3-2-4-9-20)36-27(23)32-17-31-26/h2-14,17H,15-16H2,1H3,(H,30,31,32)(H2,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370499 (CHEMBL4163926) Show SMILES OC1CCN(Cc2cccc(NC(=O)Nc3ccc(CCNc4ncnc5oc(c(Cl)c45)-c4ccccc4)cc3)c2)CC1 Show InChI InChI=1S/C33H33ClN6O3/c34-29-28-31(36-21-37-32(28)43-30(29)24-6-2-1-3-7-24)35-16-13-22-9-11-25(12-10-22)38-33(42)39-26-8-4-5-23(19-26)20-40-17-14-27(41)15-18-40/h1-12,19,21,27,41H,13-18,20H2,(H,35,36,37)(H2,38,39,42)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50206416 (CHEMBL3953964) Show SMILES CC#CC(=O)Nc1cccc(c1)-c1n[nH]c2ccc(NS(=O)(=O)c3ccccc3)cc12 Show InChI InChI=1S/C23H18N4O3S/c1-2-7-22(28)24-17-9-6-8-16(14-17)23-20-15-18(12-13-21(20)25-26-23)27-31(29,30)19-10-4-3-5-11-19/h3-6,8-15,27H,1H3,(H,24,28)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged Aurora A (123 to 401 residues) (unknown origin) preincubated for 15 mins followed by tetra(LRRWSLG) substrate addition measu...				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370446 (CHEMBL4173353) Show SMILES CCc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C23H30N6O3/c1-27-8-5-19(26-16-27)14-28-10-6-23(7-11-28,21(30)31)15-32-20-3-2-17-4-9-29(22(24)25)13-18(17)12-20/h2-3,5,8,12,16H,4,6-7,9-11,13-15H2,1H3,(H3-,24,25,30,31)/p+1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370515 (CHEMBL4171792) Show SMILES Clc1c(oc2ncnc(NCCc3ccc(NC(=O)Nc4cccc(CN5CCCCC5)c4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C33H33ClN6O2/c34-29-28-31(36-22-37-32(28)42-30(29)25-9-3-1-4-10-25)35-17-16-23-12-14-26(15-13-23)38-33(41)39-27-11-7-8-24(20-27)21-40-18-5-2-6-19-40/h1,3-4,7-15,20,22H,2,5-6,16-19,21H2,(H,35,36,37)(H2,38,39,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50370441 (CHEMBL4162635) Show SMILES CN(C)Cc1ccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)cc1 Show InChI InChI=1S/C30H29ClN6O2/c1-37(2)18-21-10-14-24(15-11-21)36-30(38)35-23-12-8-20(9-13-23)16-17-32-28-25-26(31)27(22-6-4-3-5-7-22)39-29(25)34-19-33-28/h3-15,19H,16-18H2,1-2H3,(H,32,33,34)(H2,35,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant Aurora A kinase domain (123 to 401 residues) expressed in Sf9 cells after 120 mins by kinase-glo luminesce...				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370515 (CHEMBL4171792) Show SMILES Clc1c(oc2ncnc(NCCc3ccc(NC(=O)Nc4cccc(CN5CCCCC5)c4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C33H33ClN6O2/c34-29-28-31(36-22-37-32(28)42-30(29)25-9-3-1-4-10-25)35-17-16-23-12-14-26(15-13-23)38-33(41)39-27-11-7-8-24(20-27)21-40-18-5-2-6-19-40/h1,3-4,7-15,20,22H,2,5-6,16-19,21H2,(H,35,36,37)(H2,38,39,41)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50370444 (CHEMBL4172214) Show SMILES CCN(CC)Cc1cccc(NC(=O)Nc2ccc(CCNc3ncnc4oc(c(Cl)c34)-c3ccccc3)cc2)c1 Show InChI InChI=1S/C32H33ClN6O2/c1-3-39(4-2)20-23-9-8-12-26(19-23)38-32(40)37-25-15-13-22(14-16-25)17-18-34-30-27-28(33)29(24-10-6-5-7-11-24)41-31(27)36-21-35-30/h5-16,19,21H,3-4,17-18,20H2,1-2H3,(H,34,35,36)(H2,37,38,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Aurora-B (1 to 344 residues) expressed in Sf9 cells after 90 mins by kinase-glo luminescence assay				Eur J Med Chem 151: 533-545 (2018) Article DOI: 10.1016/j.ejmech.2018.03.064 BindingDB Entry DOI: 10.7270/Q2D2216W
					More data for this Ligand-Target Pair

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