| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptase delta |
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| Ligand | BDBM50120368 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_88854 (CHEMBL697873) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Sutton, JC; Bolton, SA; Hartl, KS; Huang, MH; Jacobs, G; Meng, W; Ogletree, ML; Pi, Z; Schumacher, WA; Seiler, SM; Slusarchyk, WA; Treuner, U; Zahler, R; Zhao, G; Bisacchi, GS Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. Bioorg Med Chem Lett12:3229-33 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptase delta |
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| Name: | Tryptase delta |
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| Synonyms: | Delta-tryptase | HmMCP-3-like tryptase III | Mast cell mMCP-7-like | TPSD1 | TRYD_HUMAN | Tryptase delta | Tryptase-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26578.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104777 |
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| Residue: | 242 |
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| Sequence: | MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGP
YWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQF
YIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPY
PLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVN
GT
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| BDBM50120368 |
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| n/a |
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| Name | BDBM50120368 |
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| Synonyms: | (2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carbonyl)-3-(3-guanidino-propyl)-4-oxo-azetidine-2-carboxylic acid | (3S,4R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carbonyl)-3-(3-guanidino-propyl)-4-oxo-azetidine-2-carboxylic acid | (R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carbonyl)-3-(3-guanidino-propyl)-4-oxo-azetidine-2-carboxylic acid | 1-(4-tert-Butylcarbamoyl-piperazine-1-carbonyl)-3-(3-guanidino-propyl)-4-oxo-azetidine-2-carboxylic acid | BMS-262084 | CHEMBL71037 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H31N7O5 |
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| Mol. Mass. | 425.4826 |
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| SMILES | CC(C)(C)NC(=O)N1CCN(CC1)C(=O)N1[C@@H]([C@@H](CCCNC(N)=N)C1=O)C(O)=O |
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| Structure | 
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