Reaction Details |
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Target | m7GpppX diphosphatase |
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Ligand | BDBM50237217 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1660723 (CHEMBL4010335) |
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IC50 | 1.0±n/a nM |
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Citation | Gopalsamy, A; Narayanan, A; Liu, S; Parikh, MD; Kyne, RE; Fadeyi, O; Tones, MA; Cherry, JJ; Nabhan, JF; LaRosa, G; Petersen, DN; Menard, C; Foley, TL; Noell, S; Ren, Y; Loria, PM; Maglich-Goodwin, J; Rong, H; Jones, LH Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem60:3094-3108 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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m7GpppX diphosphatase |
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Name: | m7GpppX diphosphatase |
Synonyms: | DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS) |
Type: | Enzyme |
Mol. Mass.: | 38606.80 |
Organism: | Homo sapiens (Human) |
Description: | Q96C86 |
Residue: | 337 |
Sequence: | MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDK
IIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFP
PRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNIL
DKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPL
LRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAE
VIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
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BDBM50237217 |
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n/a |
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Name | BDBM50237217 |
Synonyms: | CHEMBL342595 |
Type | Small organic molecule |
Emp. Form. | C15H14N4O |
Mol. Mass. | 266.2979 |
SMILES | Nc1nc(N)c2c(OCc3ccccc3)cccc2n1 |
Structure |
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