| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 2 |
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| Ligand | BDBM50237810 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1661955 |
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| IC50 | 1000±n/a nM |
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| Citation |  Wang, P; Elsayed, MSA; Plescia, CB; Ravji, A; Redon, CE; Kiselev, E; Marchand, C; Zeleznik, O; Agama, K; Pommier, Y; Cushman, M Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2). J Med Chem60:3275-3288 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosyl-DNA phosphodiesterase 2 |
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| Name: | Tyrosyl-DNA phosphodiesterase 2 |
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| Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40916.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_23510348 |
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| Residue: | 362 |
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| Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
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| BDBM50237810 |
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| n/a |
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| Name | BDBM50237810 |
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| Synonyms: | CHEMBL4061238 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N5O5 |
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| Mol. Mass. | 463.4858 |
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| SMILES | COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCC(N)CC2)c(=O)c2cc(ccc12)[N+]([O-])=O |
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| Structure | 
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