Reaction Details |
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Target | Glutamate receptor 1 |
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Ligand | BDBM86754 |
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Substrate/Competitor | n/a |
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Ki | >10000±n/a nM |
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Comments | PDSP_6660 |
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Citation | Weiss, B; Alt, A; Ogden, AM; Gates, M; Dieckman, DK; Clemens-Smith, A; Ho, KH; Jarvie, K; Rizkalla, G; Wright, RA; Calligaro, DO; Schoepp, D; Mattiuz, EL; Stratford, RE; Johnson, B; Salhoff, C; Katofiasc, M; Phebus, LA; Schenck, K; Cohen, M; Filla, SA; Ornstein, PL; Johnson, KW; Bleakman, D Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo. J Pharmacol Exp Ther318:772-81 (2006) [PubMed] Article |
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More Info.: | Get all data from this article |
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Glutamate receptor 1 |
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Name: | Glutamate receptor 1 |
Synonyms: | AMPA-selective glutamate receptor 1 | GLUH1 | GLUR1 | GRIA1 | GRIA1_HUMAN | GluR-1 | GluR-A | GluR-K1 | Glutamate AMPA 1 | Glutamate receptor 1 | Glutamate receptor AMPA 1/2 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 101512.92 |
Organism: | Homo sapiens (Human) |
Description: | Glutamate AMPA 1 GRIA1 HUMAN::P42261 |
Residue: | 906 |
Sequence: | MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKW
WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMP
LGATGL
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BDBM86754 |
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n/a |
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Name | BDBM86754 |
Synonyms: | LY 466195 | LY-466195 |
Type | Small organic molecule |
Emp. Form. | C16H24F2N2O4 |
Mol. Mass. | 346.3696 |
SMILES | OC(=O)C1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O |r| |
Structure |
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