| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM284781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Phosphodiesterase (PDE) 2A and 10 Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 2530±n/a nM |
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| Comments | extracted |
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| Citation |  Hoenke, C; Bertani, B; Ferrara, M; Fossati, G; Frattini, S; Giovannini, R; Hobson, S Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide US Patent US10023575 Publication Date 7/17/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 105691.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00408 |
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| Residue: | 941 |
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| Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
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| BDBM284781 |
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| n/a |
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| Name | BDBM284781 |
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| Synonyms: | US10023575, Example 72 | US10023575, Example 73 | US10023575, Example 74 | US10023575, Example 75 | US10479794, Example 75 | US10875867, Example 75 | US11691977, Example 75 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16F4N4O3 |
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| Mol. Mass. | 424.349 |
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| SMILES | Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F |
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| Structure | 
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