Reaction Details |
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Target | Protein arginine N-methyltransferase 8 |
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Ligand | BDBM178102 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PRMT Biochemical Assays |
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Ki | 17±0.9 nM |
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IC50 | 42±3 nM |
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Citation | Eram, MS; Shen, Y; Szewczyk, MM; Wu, H; Senisterra, G; Li, F; Butler, KV; Kaniskan, Hÿ; Speed, BA; Dela Seña, C; Dong, A; Zeng, H; Schapira, M; Brown, PJ; Arrowsmith, CH; Barsyte-Lovejoy, D; Liu, J; Vedadi, M; Jin, J A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol11:772-81 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 8 |
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Name: | Protein arginine N-methyltransferase 8 |
Synonyms: | ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8) |
Type: | Protein |
Mol. Mass.: | 45293.70 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 394 |
Sequence: | MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGK
MSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS
GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVD
IIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWE
NVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQR
NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISM
KPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
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BDBM178102 |
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n/a |
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Name | BDBM178102 |
Synonyms: | N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methyl)ethane-1,2-diamine (Compound 2) |
Type | Small organic molecule |
Emp. Form. | C15H18F3N3 |
Mol. Mass. | 297.3187 |
SMILES | CN(CCN)Cc1c[nH]cc1-c1cccc(c1)C(F)(F)F |
Structure |
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