Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM236524 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Radioligand-Binding Assay |
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pH | 7.4±0 |
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Temperature | 310.15±0 K |
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Ki | 11.6±0.0 nM |
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Citation | Nirogi, RV; Kambhampati, R; Kothmirkar, P; Konda, J; Bandyala, TR; Gudla, P; Arepalli, S; Gangadasari, NP; Shinde, AK; Deshpande, AD; Dwarampudi, A; Chindhe, AK; Dubey, PK Synthesis and structure-activity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands. J Enzyme Inhib Med Chem27:443-50 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM236524 |
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n/a |
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Name | BDBM236524 |
Synonyms: | 2-Methoxy-10-[(2-N,N-dimethylamino-2-methyl)ethyl)]benzo[d]isothiazolo[3,2-a]indol-S,S-dioxide (15) |
Type | Small organic molecule |
Emp. Form. | C21H23NO3S |
Mol. Mass. | 369.477 |
SMILES | COc1ccc2C3C(=C(CC(C)N(C)C)c2c1)c1ccccc1S3(=O)=O |t:7| |
Structure |
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