| Reaction Details |
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 | Report a problem with these data |
| Target | Metallo-beta-lactamase type 2 |
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| Ligand | BDBM427551 |
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| Substrate/Competitor | n/a |
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| IC50 | 0.065±n/a nM |
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| Citation |  Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent US10544130 Publication Date 1/28/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Metallo-beta-lactamase type 2 |
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| Name: | Metallo-beta-lactamase type 2 |
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| Synonyms: | B2 metallo-beta-lactamase | BLAN1_KLEPN | Beta-lactamase NDM-1 | Beta-lactamase type II | Metallo-beta-lactamase NDM-1 | Metallo-beta-lactamase type 2 | Metallo-beta-lactamase type II | NDM-1 | New Delhi metallo-beta-lactamase-1 | blaNDM-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28498.15 |
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| Organism: | Klebsiella pneumoniae |
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| Description: | ChEMBL_103887 |
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| Residue: | 270 |
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| Sequence: | MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQ
HTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTH
AHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPL
KVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAF
PKASMIVMSHSAPDSRAAITHTARMADKLR
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| BDBM427551 |
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| n/a |
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| Name | BDBM427551 |
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| Synonyms: | 4-(2-amino-1,3- benzothiazol-4-yl)- N1-[(3- hydroxyazetidin-3- yl)methyl]-3-(2H- tetrazol-5- yl)benzene-1,2- disulfonamide | US10544130, Example 387 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N9O5S3 |
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| Mol. Mass. | 537.596 |
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| SMILES | Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NCC1(O)CNC1 |
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| Structure | 
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