| Reaction Details |
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 | Report a problem with these data |
| Target | Guanylate cyclase soluble subunit alpha-1/beta-1 |
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| Ligand | BDBM430869 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CHO Cellular Assay |
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| EC50 | 0.500±n/a nM |
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| Citation |  Adams, CM; Bevan, D; Capparelli, MP; Ehara, T; Ferrara, L; Ji, N; Meredith, E; Mogi, M; Powers, JJ; Prasanna, G; Mainolfi, N; Kato, M Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators US Patent US10550102 Publication Date 2/4/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanylate cyclase soluble subunit alpha-1/beta-1 |
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| Name: | Guanylate cyclase soluble subunit alpha-1/beta-1 |
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| Synonyms: | Soluble Guanylate Cyclases | Soluble guanylate cyclase (sGC) | Soluble guanylate cyclase alpha 1 and beta 1 subunits (sGC) | Soluble guanylate cyclase alpha1/beta1 complex | soluble guanylate cyclase activators | soluble guanylate cyclase apha 1 and soluble guanylate cyclase beta 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Guanylate cyclase soluble subunit alpha-1 |
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| Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 77457.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02108 |
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| Residue: | 690 |
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| Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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| Component 2 |
| Name: | Guanylate cyclase soluble subunit beta-1 |
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| Synonyms: | GCYB1_HUMAN | GUC1B3 | GUCSB3 | GUCY1B1 | GUCY1B3 | Guanylate cyclase soluble (GCS-beta-1) | Solube guanylate cyclase beta-1 (sGCβ1) | soluble guanylate cyclase beta-1 (sGC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 70496.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02153 |
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| Residue: | 619 |
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| Sequence: | MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
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| BDBM430869 |
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| n/a |
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| Name | BDBM430869 |
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| Synonyms: | US10550102, Example 5-3 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H35F3N4O4 |
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| Mol. Mass. | 644.6827 |
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| SMILES | CCc1cc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC1)C(=O)C1CC1 |r| |
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| Structure | 
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