| Reaction Details |
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 | Report a problem with these data |
| Target | Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
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| Ligand | BDBM451993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Protein-Protein Interaction Assay |
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| IC50 | 0.064±n/a nM |
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| Citation |  Aktoudianakis, E; Cho, A; Du, Z; Graupe, M; Lad, LT; Machicao Tello, PA; Medley, JW; Metobo, SE; Mukherjee, PK; Naduthambi, D; Parkhill, EQ; Phillips, BW; Simonovich, SP; Squires, NH; Wang, P; Watkins, WJ; Xu, J; Yang, KS; Ziebenhaus, CA PD-1/PD-L1 inhibitors US Patent US10710986 Publication Date 7/14/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
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| Name: | Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
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| Synonyms: | PD-1/PD-L1 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Programmed cell death protein 1 [25-167] |
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| Synonyms: | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 (25-167) | Programmed cell death protein 1 (aa25-167) | Protein PD-1 | hPD-1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 15954.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15116 (aa25-167) |
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| Residue: | 143 |
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| Sequence: | LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPE
DRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRV
TERRAEVPTAHPSPSPRPAGQFQ
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| Component 2 |
| Name: | Programmed cell death 1 ligand 1 [19-238] |
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| Synonyms: | B7H1 | CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 (aa19-238) | Programmed death ligand 1 | hPD-L1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25191.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NZQ7 (aa19-238) |
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| Residue: | 220 |
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| Sequence: | FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQH
SSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKIN
QRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLR
INTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNER
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| BDBM451993 |
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| n/a |
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| Name | BDBM451993 |
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| Synonyms: | US10710986, Example 133 | US11555029, No. 133 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28Cl2N8O4 |
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| Mol. Mass. | 635.501 |
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| SMILES | COc1nc(cnc1C1=NC[C@H](CO)N1)-c1cccc(c1Cl)-c1cccc(c1Cl)-c1cnc(C2=NC[C@H](CO)N2)c(OC)n1 |r,t:9,37| |
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| Structure | 
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