Reaction Details |
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Target | Serine/threonine-protein kinase TBK1 |
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Ligand | BDBM478495 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TBK1 Low ATP Kinase Assay |
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IC50 | 1.66±n/a nM |
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Citation | Schulze, V; Heinrich, T; Prinz, F; Lefranc, J; Schröder, J; Mengel, A; Bone, W; Bálint, J; Wengner, AM; Eis, K; Irlbacher, H; Koppitz, M; Bömer, U; Bader, B; Briem, H; Lienau, P; Christ, C; Stöckigt, D; Hillig, R Heteroarylbenzimidazole compounds US Patent US10894784 Publication Date 1/19/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase TBK1 |
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Name: | Serine/threonine-protein kinase TBK1 |
Synonyms: | NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN |
Type: | protein |
Mol. Mass.: | 83645.20 |
Organism: | Homo sapiens (Human) |
Description: | Q9UHD2 |
Residue: | 729 |
Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
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BDBM478495 |
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n/a |
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Name | BDBM478495 |
Synonyms: | US10894784, Example 39.02.03 | cyclopropyl(4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone (single stereoisomer A) |
Type | Small organic molecule |
Emp. Form. | C29H34N8O |
Mol. Mass. | 510.6333 |
SMILES | CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3)c2)c1 |
Structure |
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