Reaction Details |
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Target | Programmed cell death 1 ligand/protein 1 |
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Ligand | BDBM452501 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Protein-Protein Interaction Assay |
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IC50 | 0.064±n/a nM |
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Citation | Aktoudianakis, E; Cho, A; Du, Z; Graupe, M; Lad, LT; Machicao Tello, PA; Medley, JW; Metobo, SE; Mukherjee, PK; Naduthambi, D; Parkhill, EQ; Phillips, BW; Simonovich, SP; Squires, NH; Wang, P; Watkins, WJ; Xu, J; Yang, KS; Ziebenhaus, CA PD-1/PD-L1 inhibitors US Patent US11555029 Publication Date 1/17/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Programmed cell death 1 ligand/protein 1 |
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Name: | Programmed cell death 1 ligand/protein 1 |
Synonyms: | PD-1/PD-L1 | Programmed cell death protein 1/Programmed cell death 1 ligand 1 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Programmed cell death protein 1 |
Synonyms: | CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1 |
Type: | PROTEIN |
Mol. Mass.: | 31650.07 |
Organism: | Homo sapiens |
Description: | ChEMBL_108437 |
Residue: | 288 |
Sequence: | MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTS
ESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGT
YLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGS
LVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVP
CVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
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Component 2 |
Name: | Programmed cell death 1 ligand 1 |
Synonyms: | B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 |
Type: | PROTEIN |
Mol. Mass.: | 33278.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109807 |
Residue: | 290 |
Sequence: | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
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BDBM452501 |
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n/a |
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Name | BDBM452501 |
Synonyms: | US10710986, Example 642 | US11555029, No. 642 |
Type | Small organic molecule |
Emp. Form. | C31H30Cl2N6O3 |
Mol. Mass. | 605.514 |
SMILES | COc1nc(ccc1CN1CC(C)(O)C1)-c1cccc(c1Cl)-c1cccc(c1Cl)-c1cnc(C2=NCCN2)c(OC)n1 |t:37| |
Structure |
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