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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | VIM-1 protein | ||
| Ligand | BDBM367993 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Activity | ||
| IC50 | 0.196±n/a nM | ||
| Citation |  Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Metallo-beta-lactamase inhibitors US Patent US10227331 Publication Date 3/12/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| VIM-1 protein | |||
| Name: | VIM-1 protein | ||
| Synonyms: | Beta-lactamase VIM-1 | Class B carbapenemase VIM-1 | Metallo-beta-lactamase VIM-1 | Metallobeta-lactamase | VIM-1 | VIM-1 metallo-beta lactamase | VIM-1 metallo-beta-lactamase | VIM-1 protein | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 28014.53 | ||
| Organism: | Pseudomonas aeruginosa | ||
| Description: | n/a | ||
| Residue: | 266 | ||
| Sequence: |
| ||
| BDBM367993 | |||
| n/a | |||
| Name | BDBM367993 | ||
| Synonyms: | 3-(2-aminobenzo[d]thiazol-4- yl)-6-((1s,3s)-3- aminocyclobutylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide | US10227331, Example 180 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H18N8O4S3 | ||
| Mol. Mass. | 506.582 | ||
| SMILES | N[C@H]1C[C@H](C1)S(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O |r,wU:3.5,1.0,(5.93,-4.48,;5.16,-3.15,;3.68,-2.75,;4.08,-1.26,;5.56,-1.66,;3.31,.07,;4.85,.07,;4.39,1.16,;1.77,.07,;1,-1.26,;-.54,-1.26,;-1.31,.07,;-2.85,.07,;-3.62,1.4,;-5.16,1.4,;-5.93,.07,;-5.16,-1.26,;-5.64,-2.73,;-4.39,-3.63,;-4.39,-5.17,;-3.15,-2.73,;-3.62,-1.26,;-.54,1.4,;-1.31,2.74,;-2.85,2.9,;-3.17,4.4,;-1.83,5.17,;-.69,4.14,;1.02,1.45,;1.79,2.78,;3.13,2.01,;2.56,4.12,;.46,3.55,)| | ||
| Structure | 
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