| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TBK1 |
|---|
| Ligand | BDBM278162 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assays for TBK1 and IKKe |
|---|
| IC50 | 2.00±n/a nM |
|---|
| Citation |  Du, Z; Guerrero, JA; Kaplan, JA; Knox, Jr., JE; Lo, JR; Mitchell, SA; Naduthambi, D; Phillips, BW; Venkataramani, C; Wang, P; Watkins, WJ; Zhao, Z Tank-binding kinase inhibitor compounds US Patent US10253019 Publication Date 4/9/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase TBK1 |
|---|
| Name: | Serine/threonine-protein kinase TBK1 |
|---|
| Synonyms: | NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN |
|---|
| Type: | protein |
|---|
| Mol. Mass.: | 83645.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UHD2 |
|---|
| Residue: | 729 |
|---|
| Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
|
|
|
|---|
| BDBM278162 |
|---|
| n/a |
|---|
| Name | BDBM278162 |
|---|
| Synonyms: | 2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-((R)-3-(hydroxymethyl)morpholino)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile | US10040781, Example 384 | US10253019, Example 384 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H30FN7O5 |
|---|
| Mol. Mass. | 563.5801 |
|---|
| SMILES | OC[C@@H]1COCCN1c1ccc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(C[C@H]3F)C(=O)CO)c(c2)C#N)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
