Reaction Details |
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Target | Cholesteryl ester transfer protein |
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Ligand | BDBM50250357 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1681594 |
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IC50 | 240±n/a nM |
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Citation | Yamada, K; Brousseau, M; Honma, W; Iimura, A; Imase, H; Iwaki, Y; Kawanami, T; LaSala, D; Liang, G; Mitani, H; Nonomura, K; Ohmori, O; Pan, M; Rigel, DF; Umemura, I; Yasoshima, K; Zhu, G; Mogi, M Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma. J Med Chem60:8466-8481 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholesteryl ester transfer protein |
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Name: | Cholesteryl ester transfer protein |
Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
Type: | Enzyme |
Mol. Mass.: | 54751.53 |
Organism: | Homo sapiens (Human) |
Description: | P11597 |
Residue: | 493 |
Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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BDBM50250357 |
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n/a |
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Name | BDBM50250357 |
Synonyms: | CHEMBL4089133 |
Type | Small organic molecule |
Emp. Form. | C31H35BrClF3N4O2 |
Mol. Mass. | 667.987 |
SMILES | CC[C@@H]1C[C@@H](C[C@H](Cc2ccccc2)N1C(=O)OC(C)(C)C)N(Cc1cc(Cl)cc(c1)C(F)(F)F)c1ncc(Br)cn1 |r| |
Structure |
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