Reaction Details |
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Target | Tyrosyl-DNA phosphodiesterase 2 |
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Ligand | BDBM50378160 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1737948 (CHEMBL4153698) |
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IC50 | 3100±n/a nM |
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Citation | Yu, LM; Hu, Z; Chen, Y; Ravji, A; Lopez, S; Plescia, CB; Yu, Q; Yang, H; Abdelmalak, M; Saha, S; Agama, K; Kiselev, E; Marchand, C; Pommier, Y; An, LK Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2). Eur J Med Chem151:777-796 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosyl-DNA phosphodiesterase 2 |
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Name: | Tyrosyl-DNA phosphodiesterase 2 |
Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40916.54 |
Organism: | Homo sapiens (Human) |
Description: | gi_23510348 |
Residue: | 362 |
Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
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BDBM50378160 |
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n/a |
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Name | BDBM50378160 |
Synonyms: | CHEMBL4161684 |
Type | Small organic molecule |
Emp. Form. | C13H8N2O5 |
Mol. Mass. | 272.213 |
SMILES | CCOC(=O)c1noc2c1C(=O)c1ncccc1C2=O |
Structure |
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