| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50239063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1746163 (CHEMBL4180673) |
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| Kd | 14±n/a nM |
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| Citation |  Barbay, JK; Cummings, MD; Abad, M; Castro, G; Kreutter, KD; Kummer, DA; Maharoof, U; Milligan, C; Nishimura, R; Pierce, J; Schalk-Hihi, C; Spurlino, J; Tanis, VM; Urbanski, M; Venkatesan, H; Wang, A; Woods, C; Wolin, R; Xue, X; Edwards, JP; Fourie, AM; Leonard, K 6-Substituted quinolines as ROR?t inverse agonists. Bioorg Med Chem Lett27:5277-5283 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50239063 |
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| n/a |
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| Name | BDBM50239063 |
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| Synonyms: | CHEMBL4094197 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H18Cl2N4O |
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| Mol. Mass. | 461.343 |
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| SMILES | Cn1cncc1C(O)(c1ccncc1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1 |
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| Structure | 
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