| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase A |
|---|
| Ligand | BDBM50479533 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_495302 (CHEMBL1006294) |
|---|
| IC50 | 1937±n/a nM |
|---|
| Citation |  Coumar, MS; Leou, JS; Shukla, P; Wu, JS; Dixit, AK; Lin, WH; Chang, CY; Lien, TW; Tan, UK; Chen, CH; Hsu, JT; Chao, YS; Wu, SY; Hsieh, HP Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity. J Med Chem52:1050-62 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase A |
|---|
| Name: | Aurora kinase A |
|---|
| Synonyms: | AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 45830.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14965 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
|
|
|
|---|
| BDBM50479533 |
|---|
| n/a |
|---|
| Name | BDBM50479533 |
|---|
| Synonyms: | CHEMBL460728 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21N7O2 |
|---|
| Mol. Mass. | 367.405 |
|---|
| SMILES | COc1ccc(\C=N\Nc2[nH]nc(C)c2C(=O)NCCc2c[nH]cn2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
