| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C11 |
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| Ligand | BDBM50505789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1824033 (CHEMBL4323797) |
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| IC50 | >30000±n/a nM |
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| Citation |  Wortmann, L; Lindenthal, B; Muhn, P; Walter, A; Nubbemeyer, R; Heldmann, D; Sobek, L; Morandi, F; Schrey, AK; Moosmayer, D; Günther, J; Kuhnke, J; Koppitz, M; Lücking, U; Röhn, U; Schäfer, M; Nowak-Reppel, K; Kühne, R; Weinmann, H; Langer, G Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo. J Med Chem62:10321-10341 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C11 |
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| Name: | Cytochrome P450 2C11 |
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| Synonyms: | CP2CB_RAT | Cyp2c | Cyp2c-11 | Cyp2c11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57187.48 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_100121 |
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| Residue: | 500 |
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| Sequence: | MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKKFSKV
YGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQW
KEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICS
IIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYI
KNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTE
TTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYID
LVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFK
KSDYFMPFSAGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLP
PFYEACFIPVQRADSLSSHL
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| BDBM50505789 |
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| n/a |
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| Name | BDBM50505789 |
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| Synonyms: | CHEMBL4471621 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18Cl2N2O2S |
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| Mol. Mass. | 433.351 |
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| SMILES | COc1ccc(cc1)[C@@H]1N(CCc2sccc12)C(=O)Nc1cc(Cl)cc(Cl)c1 |r| |
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| Structure | 
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