| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50520933 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1882438 (CHEMBL4383937) |
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| Ki | 1230±n/a nM |
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| Citation |  Szczepa?ska, K; Karcz, T; Kota?ska, M; Siwek, A; Kuder, KJ; Latacz, G; Mogilski, S; Hagenow, S; Lubelska, A; Sobolewski, M; Stark, H; Kie?-Kononowicz, K Optimization and preclinical evaluation of novel histamine H Bioorg Med Chem26:6056-6066 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50520933 |
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| n/a |
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| Name | BDBM50520933 |
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| Synonyms: | CHEMBL4467220 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N4O2 |
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| Mol. Mass. | 354.446 |
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| SMILES | CC(=O)c1ccc(OCCCCN2CCN(CC2)c2ncccn2)cc1 |
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| Structure | 
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