| Reaction Details |
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 | Report a problem with these data |
| Target | MAP/microtubule affinity-regulating kinase 4 |
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| Ligand | BDBM50537742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1970724 |
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| IC50 | >100000±n/a nM |
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| Citation |  Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Discovery and optimization of heteroaryl piperazines as potent and selective PI3K? inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP/microtubule affinity-regulating kinase 4 |
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| Name: | MAP/microtubule affinity-regulating kinase 4 |
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| Synonyms: | KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MARK4 | MARK4_HUMAN | MARKL1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82561.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774620 |
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| Residue: | 752 |
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| Sequence: | MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR
LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK
LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR
DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW
SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT
LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV
TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR
RHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAH
NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVP
PASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE
AAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPW
SVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLP
RPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
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| BDBM50537742 |
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| n/a |
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| Name | BDBM50537742 |
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| Synonyms: | CHEMBL4634634 | US11179389, Compound 1-14 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N7O |
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| Mol. Mass. | 365.4322 |
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| SMILES | C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 |r| |
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| Structure | 
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