Reaction Details |
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Target | Arginase-1 |
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Ligand | BDBM50577464 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2130269 (CHEMBL4839698) |
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IC50 | 20±n/a nM |
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Citation | Lu, M; Zhang, H; Li, D; Childers, M; Pu, Q; Palte, RL; Gathiaka, S; Lyons, TW; Palani, A; Fan, PW; Spacciapoli, P; Miller, JR; Cho, H; Cheng, M; Chakravarthy, K; O'Neil, J; Eangoor, P; Beard, A; Kim, HY; Saurí, J; Gunaydin, H; Sloman, DL; Siliphaivanh, P; Cumming, J; Fischer, C Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. ACS Med Chem Lett12:1380-1388 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Arginase-1 |
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Name: | Arginase-1 |
Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
Type: | PROTEIN |
Mol. Mass.: | 34737.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_978893 |
Residue: | 322 |
Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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BDBM50577464 |
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n/a |
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Name | BDBM50577464 |
Synonyms: | CHEMBL4863489 |
Type | Small organic molecule |
Emp. Form. | C9H19BN2O4 |
Mol. Mass. | 230.069 |
SMILES | CN[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O |r| |
Structure |
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