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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50249081
Substrate/Competitorn/a
Meas. Tech.ChEMBL_500342 (CHEMBL973434)
IC50 1090±n/a nM
Citation Yang, HShen, YChen, JJiang, QLeng, YShen, J Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors. Eur J Med Chem44:1167-71 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50249081
n/a
NameBDBM50249081
Synonyms:CHEMBL452136 | N'-(2,4-dihydroxy-6-methylbenzylidene)-2-(m-tolyloxy)acetohydrazide
TypeSmall organic molecule
Emp. Form.C17H18N2O4
Mol. Mass.314.3358
SMILESCc1cccc(OCC(=O)NN=Cc2c(C)cc(O)cc2O)c1 |w:11.10|
Structure
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