Reaction Details |
| Report a problem with these data |
Target | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
---|
Ligand | BDBM50304789 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_605924 (CHEMBL1068541) |
---|
IC50 | 320±n/a nM |
---|
Citation | Choi, H; Lee, J; Kim, YH; Im, DS; Hwang, IC; Kim, SJ; Moon, SK; Lee, HW; Lee, SS; Ahn, SK; Kim, SW; Choi, NS; Lee, KJ Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533). Bioorg Med Chem Lett20:383-6 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
---|
Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
Synonyms: | PDE6A | PDE6A_BOVIN | PDEA | Phosphodiesterase 6 | Phosphodiesterase 6A |
Type: | Enzyme |
Mol. Mass.: | 99320.22 |
Organism: | Bos taurus (Bovine) |
Description: | P11541 |
Residue: | 859 |
Sequence: | MGEVTAEEVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNSVEESEI
IFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNGIAELATRLFNVHKDAV
LEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVPNTEEDEHFCDFVDTLTEYQTKNILAS
PIMNGKDVVAIIMVVNKVDGPHFTENDEEILLKYLNFANLIMKVFHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAP
PYAGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIM
NAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMVKYHVKCDNEEIQTILKTREVYGKEPW
ECEEEELAEILQGELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLDQTRKEIVMAMMMTACD
LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYETKMKGLEEEKQKQQAANQAAAGS
QHGGKQPGGGPASKSCCVQ
|
|
|
BDBM50304789 |
---|
n/a |
---|
Name | BDBM50304789 |
Synonyms: | CHEMBL604271 | N-(4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-yl)-N-methylpropionamide |
Type | Small organic molecule |
Emp. Form. | C23H27ClN4O4 |
Mol. Mass. | 458.938 |
SMILES | CCC(=O)N(C)c1cc2c(NCc3ccc(OC)c(Cl)c3)ncnc2c(CCO)c1OC |
Structure |
|