| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential M8 protein |
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| Ligand | BDBM50380697 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_813323 (CHEMBL2019444) |
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| IC50 | 138±n/a nM |
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| Citation |  Matthews, JM; Qin, N; Colburn, RW; Dax, SL; Hawkins, M; McNally, JJ; Reany, L; Youngman, MA; Baker, J; Hutchinson, T; Liu, Y; Lubin, ML; Neeper, M; Brandt, MR; Stone, DJ; Flores, CM The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists. Bioorg Med Chem Lett22:2922-6 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential M8 protein |
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| Name: | Transient receptor potential M8 protein |
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| Synonyms: | Cold-menthol receptor (TRPM8) | TRPM8 Receptor | Transient receptor potential M8 protein | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential melastatin subfamily, type 8 (TRPM8) |
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| Type: | Enzyme |
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| Mol. Mass.: | 127589.43 |
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| Organism: | Canis lupus familiaris (Dog) |
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| Description: | Q1A7N1 |
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| Residue: | 1104 |
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| Sequence: | MSFEGARLSMRNRRNGTLDSTRTLYSSTSRSTDVSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHIEGTQINSNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLLRNCDAEGYFSAQY
IMDDFKRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGRETLKAINTSIKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSVVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLANEEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTNDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
SSRDDIDVELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPIDKH
KKILWYYVAFFTSPFVVFAWNVVFYIAFLLLFAYVLLMDFHSVPHSPELVLYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHPSNKTSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEHRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFGCCCREKHAEPSACCFRNEDNETLAWEGVMKENYLVKINTKANDTSQEMRH
RFRQLDTKINDLKGLLKEIANKIK
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| BDBM50380697 |
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| n/a |
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| Name | BDBM50380697 |
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| Synonyms: | CHEMBL2017513 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24F3O3PS |
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| Mol. Mass. | 456.458 |
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| SMILES | CCOP(=O)(OCC)C(Cc1cccc(c1)C(F)(F)F)c1sc2ccccc2c1C |
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| Structure | 
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