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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Apoptosis regulator Bcl-2 | ||
| Ligand | BDBM50384325 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_818165 (CHEMBL2033942) | ||
| IC50 | 24±n/a nM | ||
| Citation |  Schroeder, GM; Wei, D; Banfi, P; Cai, ZW; Lippy, J; Menichincheri, M; Modugno, M; Naglich, J; Penhallow, B; Perez, HL; Sack, J; Schmidt, RJ; Tebben, A; Yan, C; Zhang, L; Galvani, A; Lombardo, LJ; Borzilleri, RM Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorg Med Chem Lett22:3951-6 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Apoptosis regulator Bcl-2 | |||
| Name: | Apoptosis regulator Bcl-2 | ||
| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein | ||
| Type: | Homodimer or heterodimer | ||
| Mol. Mass.: | 26269.11 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P10415 | ||
| Residue: | 239 | ||
| Sequence: |
| ||
| BDBM50384325 | |||
| n/a | |||
| Name | BDBM50384325 | ||
| Synonyms: | CHEMBL2030860 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C42H41N5O5S | ||
| Mol. Mass. | 727.87 | ||
| SMILES | CCCCc1c(c(CO)nn1-c1ccccc1)-c1ccc(cc1C(=O)N1Cc2ccccc2C[C@H]1CN)C(=O)NS(=O)(=O)c1ccc2ccccc2c1 |r,wU:34.39,(11.77,-38.55,;13.06,-39.38,;14.43,-38.69,;14.52,-37.15,;15.9,-36.45,;17.32,-35.86,;17.2,-34.32,;18.37,-33.32,;18.08,-31.81,;15.7,-33.96,;14.89,-35.28,;13.36,-35.29,;12.58,-33.96,;11.04,-33.97,;10.28,-35.31,;11.07,-36.64,;12.6,-36.63,;18.63,-36.66,;19.98,-35.92,;21.31,-36.73,;21.26,-38.28,;19.91,-39.01,;18.59,-38.2,;17.24,-38.93,;15.93,-38.12,;17.2,-40.47,;18.51,-41.27,;18.46,-42.82,;19.77,-43.62,;19.72,-45.16,;18.36,-45.89,;17.05,-45.07,;17.1,-43.54,;15.8,-42.73,;15.84,-41.2,;14.53,-40.39,;13.18,-41.12,;22.57,-39.08,;23.93,-38.35,;22.53,-40.62,;23.84,-41.42,;24.63,-40.1,;25.38,-41.45,;23.8,-42.97,;22.44,-43.7,;22.39,-45.24,;23.72,-46.05,;23.7,-47.6,;25.02,-48.39,;26.38,-47.63,;26.39,-46.09,;25.07,-45.3,;25.11,-43.77,)| | ||
| Structure | 
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