Reaction Details |
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Target | Renin |
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Ligand | BDBM50402218 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_885261 (CHEMBL2214689) |
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IC50 | 8.4±n/a nM |
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Citation | Mori, Y; Ogawa, Y; Mochizuki, A; Nakamura, Y; Sugita, C; Miyazaki, S; Tamaki, K; Matsui, Y; Takahashi, M; Nagayama, T; Nagai, Y; Inoue, S; Nishi, T Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors. Bioorg Med Chem Lett22:7677-82 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50402218 |
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n/a |
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Name | BDBM50402218 |
Synonyms: | CHEMBL2204733 |
Type | Small organic molecule |
Emp. Form. | C26H40ClN5O3 |
Mol. Mass. | 506.08 |
SMILES | CC(C)C[C@@H](NC(=O)[C@@H]1CNC[C@@H](C1)N1CC(=O)N(CC1(C)C)c1ccccc1Cl)C(=O)N(C)C |r| |
Structure |
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