| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Ligand | BDBM50190101 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1591093 (CHEMBL3829061) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  LaPorte, MG; Wang, Z; Colombo, R; Garzan, A; Peshkov, VA; Liang, M; Johnston, PA; Schurdak, ME; Sen, M; Camarco, DP; Hua, Y; Pollock, NI; Lazo, JS; Grandis, JR; Wipf, P; Huryn, DM Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorg Med Chem Lett26:3581-5 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Name: | Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
|---|
| Type: | Cytosolic Transcription Factor |
|---|
| Mol. Mass.: | 87327.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
|---|
| Residue: | 750 |
|---|
| Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
|
|
|
|---|
| BDBM50190101 |
|---|
| n/a |
|---|
| Name | BDBM50190101 |
|---|
| Synonyms: | CHEMBL3827334 | US11111253, Compound 27 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20Cl2N6S |
|---|
| Mol. Mass. | 447.384 |
|---|
| SMILES | CC(C)CC1Sc2nnc(-c3[nH]nc4CCCc34)n2N=C1c1ccc(Cl)c(Cl)c1 |c:22| |
|---|
| Structure | 
|
|---|
Search and Browse
