Reaction Details |
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Target | Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
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Ligand | BDBM452501 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Protein-Protein Interaction Assay |
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IC50 | 0.064±n/a nM |
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Citation | Aktoudianakis, E; Cho, A; Du, Z; Graupe, M; Lad, LT; Machicao Tello, PA; Medley, JW; Metobo, SE; Mukherjee, PK; Naduthambi, D; Parkhill, EQ; Phillips, BW; Simonovich, SP; Squires, NH; Wang, P; Watkins, WJ; Xu, J; Yang, KS; Ziebenhaus, CA PD-1/PD-L1 inhibitors US Patent US10710986 Publication Date 7/14/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
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Name: | Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
Synonyms: | PD-1/PD-L1 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Programmed cell death protein 1 [25-167] |
Synonyms: | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 (25-167) | Programmed cell death protein 1 (aa25-167) | Protein PD-1 | hPD-1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 15954.64 |
Organism: | Homo sapiens (Human) |
Description: | Q15116 (aa25-167) |
Residue: | 143 |
Sequence: | LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPE
DRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRV
TERRAEVPTAHPSPSPRPAGQFQ
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Component 2 |
Name: | Programmed cell death 1 ligand 1 [19-238] |
Synonyms: | B7H1 | CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 (aa19-238) | Programmed death ligand 1 | hPD-L1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25191.31 |
Organism: | Homo sapiens (Human) |
Description: | Q9NZQ7 (aa19-238) |
Residue: | 220 |
Sequence: | FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQH
SSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKIN
QRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLR
INTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNER
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BDBM452501 |
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n/a |
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Name | BDBM452501 |
Synonyms: | US10710986, Example 642 | US11555029, No. 642 |
Type | Small organic molecule |
Emp. Form. | C31H30Cl2N6O3 |
Mol. Mass. | 605.514 |
SMILES | COc1nc(ccc1CN1CC(C)(O)C1)-c1cccc(c1Cl)-c1cccc(c1Cl)-c1cnc(C2=NCCN2)c(OC)n1 |t:37| |
Structure |
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