| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK [386-659] |
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| Ligand | BDBM467845 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Lanthascreen Binding Assay |
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| IC50 | 12.6±n/a nM |
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| Citation |  Arora, N; Bacani, GM; Barbay, JK; Bembenek, SD; Cai, M; Chen, W; Deckhut, CP; Edwards, JP; Ghosh, B; Hao, B; Kreutter, KD; Li, G; Tichenor, MS; Venable, JD; Wei, J; Wiener, JJ; Wu, Y; Zhu, Y; Zhang, F; Zhang, Z; Xiao, K Inhibitors of Bruton's tyrosine kinase and methods of their use US Patent US10822348 Publication Date 11/3/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BTK [386-659] |
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| Name: | Tyrosine-protein kinase BTK [386-659] |
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| Synonyms: | AGMX1 | ATK | BPK | BTK | BTK_HUMAN | Tyrosine-protein kinase BTK (386-659) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 31815.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 386-659 |
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| Residue: | 274 |
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| Sequence: | STAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEE
AKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV
CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSP
PEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEK
VYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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| BDBM467845 |
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| n/a |
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| Name | BDBM467845 |
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| Synonyms: | (R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(6-phenoxypyridin-3-yl)- 4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide; | US10800792, Example 506 | US10822348, Example 506 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24N6O4S |
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| Mol. Mass. | 540.593 |
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| SMILES | C=CC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)nc4)c(=O)[nH]c1c23 |r| |
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| Structure | 
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